Effect of Acorus tatarinowii Supercritical Extract on Behavior of Depression Model Rats
To investigate the effects of supercritical extract of Acorus tatarinowii on behavior of depression model rats. Methods 80 successful rats were divided into model group, low-dose group, middle-dose group and high-dose group according to different experimental treatment methods. Each group consisted of 20 rats. Depressive rats were treated by intragastric administration of 0.05 g/100 g, 0.10 g/100 g and 0.15 g/100 g respectively. Twenty normal rats were taken as blank group, and sugar preference, water preference, sugar preference and water preference of each group were observed. The fixed time of forced swimming and the scores of open-field sports were observed and scored. Results On the first day of the experiment, the preference for sugar and water in model group and low, medium and high dose group was significantly lower than that in blank group [(55.1 +3.6)%, (54.7 +2.5)%, (55.8 +3.4)%, (54.9 +2.8)% vs. (80.1 +2.6)%] (P < 0.05). On the 28th day of the experiment, the preference for sugar and water in low, medium and high dose group was higher than that in model group [(62.0 +4.5)%, (72.5)%]. 5 (+4.9)%, (77.8 (+3.8)% vs (54.8 (+3.2)%)] (P < 0.05), and the middle dose group was higher than the low dose group (P < 0.05). On the 28th day of the experiment, the immobility time of the low, middle and high dose groups was less than that of the model group [(112.0 + 5.4) s, (91.8 + 3.6) s, (78.4 + 4.9).
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